Unpleasant symptoms: The nausea and vomiting did not go away right at 12 weeks, like I had hoped it would. I continued to have the constant nausea and need Zofran in order to be able to eat until about 16-17 weeks. Then, it slowly ebbed and I started to feel like my old self. Hallelujah! Once I stopped taking the Zofran, the constipation also got a lot better, although I continued to need Colace. The heartburn on the other hand, starting increasing as the nausea decreased. But I will take heartburn over constant nausea any day! I can manage the heartburn by eating smaller meals, staying upright after I eat, and with drugs when necessary. Other than that, the second trimester felt like a breeze compared to the first- I had a lot more energy and overall felt pretty good.